Daim ntawv thov ntawm sodium butyrate hauv cov khoom lag luam qaib: tso cov yam ntxwv, kev nqis tes ua, thiab xaiv cov tswv yim
I. Qhov tseem ceeb ntawm cov khoom tso tawm chaw
Qhov tso tawm sijhawm thiab qhov chaw nyob ntawm cov sodium sib txawv butherpate nyob rau hauv lub plab hnyuv loj heev cuam tshuam rau lawv cov txiaj ntsig:
Thaum Ntxov - tso cov qauv tsim (piv txwv li, cov hom tsis sib xws):Ua feem ntau nyob rau hauv tus foregut, txhawb kev loj hlob ntawm tog neeg hauv cov hnyuv thiab txhim kho cov zaub mov noj thiab nqus tau cov khoom noj muaj txiaj ntsig.
{- tso cov qauv tsim (piv txwv li, coated hom):Lub Hom Phiaj Hindgut, ntau dua inhibiting qhov proliferation ntawm cov kab mob pathogenic hauv cecum.
Qee tus coated sodium butyrate:Tshaj tawm thoob plaws tag nrho cov hnyuv, ua rau nws haum rau nqaij qaib ntawm txhua theem kev loj hlob.
Ii. Mostry Kev Mob plab yam ntxwv thiab Butyrate Revingchism
Nqaij qaib tsis muaj cov hnyuv hnyuv, thiab cov ph thiab lub sijhawm hloov pauv ntawm chyme sib txawv sib txawv ntu ntu sib txawv ntu ntu. Kev siv nyiaj ua haujlwm ntawm Butyrate khoom nyob ntawm Butyrate'sPKA Tus Nqi (4.82)Thiab cov pH ib puag ncig hauv lub plab zom mov:
PH <4.82:Butyrate feem ntau muaj nyob rau hauv nws tsis yog -}}}}}}}}} Txhaws cov teeb meem cell franrrances thiab ntau dua cov kev cuam tshuam tua hluav taws.
Ph=4.82:Qhov sib piv ntawm Butyric acid rau Butyrate ions / hydrogen ions / hydrogen ions yog 1: 1.
PH> 4.82:Butyrate nyooj rau kev sib cais rau hauv ions thiab hydrogen ions, feem ntau yog ib lub zog rau cov hnyuv txhad epithelial.
III. Txoj kev nqus cov txiaj ntsig ntawm sodium butyrate
Qhov nqus ntawm Sodium Butyrate tshwm sim hauv plaub theem:
Hydrolysis Theem:Sodium Butyrate yog hydrolyzed rau hauv butyric acid nyob rau hauv lub zom zaub ntsuab.
Pais plab tiv thaiv theem:Nyob rau hauv cov acidic ib puag ncig ntawm cov qoob loo, Proventerriculus, thiab gizzard, butyric acid tseem nyob rau hauv nws daim ntawv dispociated molecular daim ntawv, tswj hwmMUC Gene Qhia Kev Taw QhiaNyob rau hauv goblet hlwb, txhim kho plab hnyuv mucus txheej, thiab tiv thaiv cov gizzard.
Cov theem hnyuv hnyuv nqus theem me me:Butyric acid tau nrawm nrawm ntawm plab hnyuv epithelial cells ntawm pass diffusion, txhawb kev loj hlob thiab rov txuas dua ntawm lub tsev.
Hindgut Act theem:Nyob rau hauv qhov siab dua part ib puag ncig ntawm hindgut, qee cov butyric acid yog hydrolyzed rau hauv butyrate ions, uas yog nqus rau lub zog los ntawm kev sib txawv,HCO₃⁻ Txauv, lossis nquag thauj khoom (MCT1, SMCT1).
IV. Cov yam ntxwv ntawm cov qauv sib txawv
Tag nrho cov khoom lag luam:Muaj cov kev sib zog qis ntawm sodium butyrate thiab yuav tsum muaj cov tshuaj ntau dua kom txhim kho kev ua tiav ntau lawm. Cov qauv tsim tawm hauv lub hindgut.
Cov khoom lag luam tsis muaj ntaub ntawv:Tso tawm sai sai nyob rau hauv foregut, exerting tshuaj tua kab mob thiab txo cov kab mob hauv cov hnyuv sab hauv plab.
Qee cov txheej txheem coated:Muab cov ntawv xa tawm thoob plaws txhua txoj hnyuv, ntsuas cov tshuaj tua kab mob thiab lub zog {{}}} kev cuam tshuam.
V. Kev sib raug zoo ntawm sodium butyrate thiab plab hnyuv ua haujlwm
Ntau lawm ...
Muab lub zog rau cov hnyuv paug epithelial lub hlwb, nce villus qhov siab, ntom ntom ntom, thiab nqus cov chaw noj mov zoo nkauj.
Stimulates lub khab nias kom zais cov zom zom mov enzymes (amylase, lipase), txhim kho kev zom plab.
Kev tswj hwmMUC Gene Qhia Kev Taw QhiaTxhawm rau ua kom zoo rau cov hnoos qeev txheej thiab ua haujlwm.
Mob plab hnyuv morphology:
Txhawb cov neeg nyob hauv tsev loj hlob thiab sib txawv, txhim kho txoj hnyuv sab nrauv thiab kev tiv thaiv kev puas tsuaj epithelial puas.
Hloov kho lub tsev loj - rau -}} srypt piv:
Muaj piv txwv (ntev villa, ntiav cryps):Txhawb kev nqus cov khoom noj muaj txiaj ntsig zoo.
Tsawg Piv (Sib Nqus Cryps):Nce tau raug mob raws plab kom raws plab thiab txo cov kab mob tsis kam.
Hnub nyoog txawv:Qhov tseem ceeb txhim kho hauv plab hnyuv moulphology yog pom nyob rau hauv 21 -}} hnub nyoog txawv tom qab 42 hnub raws li lub plab hnyuv tom ntej.
Hnyuv puab txuj txwv:
Tsis -}} dissociated butyric acid pentrates cov kab mob ib qho, inhibiting txoj kev loj hlob ntawm pathogens xws liTus ntses siavthiabClostridium perfringensens.
Txo txoj hnyuv Ph, txhawb nqa qhov muaj txiaj ntsig ntawm cov kab mob muaj txiaj ntsig xws liLactobacillusthiabBifidobacterium, yog li txhim kho cov kev sib tw zoo.
VI. Cov Tswv Cuab Khoom Xaiv
Cov me nyuam qaib (thaum ntxov):Uncoated sodium butyrate raug pom zoo kom tsis txhob muaj kev loj hlob ntawm lub nra thiab kom txhim kho sai sai FOREGUT HUV.
Kev loj hlob thiab fattening theem lossis cov neeg laus nqaij qaib:Coated formulations tuaj yeem raug xaiv kom ua tiav cov phiaj xwm kev ua hauv Hindgut.
Cov kev xav tau:Xaiv daim ntawv hloov pauv hloov tau ntawm cov teeb meem tshwj xeeb (piv txwv li, foregut patogen inhibition, hindgut microbiota kev hloov kho).