Dab tsi yogIvermectin ntsiav tshuaj?
Pharmacodynamics:Ivermectin muaj txiaj ntsig zoo rau ob qho tib si sab hauv nematodes thiab sab nraud arthropods. Nws cov txheej txheem anthelmintic suav nrog kev txhawb nqa kev tso tawm ntawm gamma-aminobutyric acid (GABA) los ntawm presynaptic neurons, yog li qhib GABA-gated chloride channels. Ivermectin kuj qhia txog kev xaiv thiab kev sib raug zoo siab rau glutamate-gated chloride channels nyob ze GABA- cov chaw nruab nrab hauv cov paj hlwb thiab cov leeg hlwb, cuam tshuam cov teeb liab neuromuscular, ua rau cov kab mob tuag tes tuag taw thiab tom qab tuag lossis raug tshem tawm. Nws qhov chaw ntawm kev ua nyob rau hauv nematodes yog cov inhibitory interneurons thiab excitatory motor neurons, thaum nyob rau hauv arthropods, nws ua nyob rau hauv lub neuromuscular hlws ris. Nws ua kom pom kev ua tau zoo ntawm 97% -100% tiv thaiv Haemonchus contortus, Ostertagia circumcincta, Cooperia spp., Trichostrongylus spp. (xws li T. axei), Strongylus spp., Bunostomum trigonocephalum, Nematodirus spp., Trichuris ovis, Oesophagostomum spp., Dictyocaulus filaria, as well as laus Chabertia ovina thiab plaub-stage. larvae in sheep. Nws kuj tseem muaj txiaj ntsig zoo rau cov kab mob arthropods xws li yoov larvae, mites, thiab ntshauv, txawm tias me ntsis tsis zoo tiv thaiv cov ntshauv (Damalinia spp.) thiab yaj keds (Melophagus ovinus). Ivermectin zoo heev tiv thaiv zuam thiab yoov yug me nyuam hauv cov quav. Txawm hais tias nws tsis tuaj yeem tua cov zuam tam sim ntawd, nws cuam tshuam rau kev pub mis, molting, thiab qe- tso, yog li txo qhov muaj peev xwm ntawm kev loj hlob. Nws cov nyhuv ntawm cov ntshav- nqus yoov zoo ib yam. Hauv npua, nws ua tiav 94% -100% kev ua tau zoo tiv thaiv cov neeg laus thiab tsis paub tab ntawm Ascaris suum, Hyostrongylus rubidus, Strongyloides ransomi, Trichuris suis, Oesophagostomum spp., Metastrongylus spp., thiab Stephanurus dentatus. Nws muaj txiaj ntsig zoo tiv thaiv plab hnyuv Trichinella spiralis (txawm tias tsis muaj txiaj ntsig tawm tsam cov leeg-theem larvae) thiab muab kev tswj zoo ntawm Haematopinus suis thiab Sarcoptes scabiei var. suis. Nws tsis muaj txiaj ntsig tiv thaiv trematodes thiab cestodes.
Pharmacokinetics:Lub pharmacokinetics ntawm ivermectin sib txawv heev nyob ntawm seb cov tsiaj hom, formulation, thiab txoj kev ntawm kev tswj. Kev txhaj tshuaj subcutaneous muab bioavailability ntau dua li kev tswj hwm qhov ncauj, tab sis qhov ncauj nqus tau nrawm dua. Tom qab nqus tau, nws faib tau zoo rau feem ntau cov ntaub so ntswg tab sis tsis zoo nkag mus rau hauv cov kua cerebrospinal. Qhov pom meej ntim ntawm kev faib tawm yog 4.6 L / kg hauv yaj thiab 4 L / kg hauv npua. Nws muaj qhov ntev ib nrab- lub neej nyob rau hauv feem ntau cov tsiaj, kwv yees li 2-7 hnub hauv yaj thiab 0.5 hnub hauv npua. Ivermectin yog metabolized hauv daim siab, feem ntau ntawm hydroxylation hauv yaj thiab methylation hauv npua. Nws yog tsuas yog tawm hauv cov quav, nrog tsawg dua 5% tshem tawm tsis hloov lossis ua cov metabolites hauv cov zis. Txog li 5% ntawm cov koob tshuaj yuav raug tso tawm hauv cov mis nyuj ntawm cov tsiaj lactating.
Dab tsi yog Physicochemical Properties ntawmIvermectin ntsiav tshuaj?
Cov khoom no yog ib ntsiav tshuaj dawb.
Siv
Dab tsi yogIvermectin ntsiav tshuaj siv rau?
Macrolide antiparasitic tus neeg sawv cev. Siv rau kev tiv thaiv thiab kho cov kab mob nematode, mite infestations, thiab kab mob cab kab mob hauv yaj thiab npua.
Kev noj tshuaj
Ntau npaum li casIvermectin ntsiav tshuajyuav tsum muab rau ib tug tsiaj?
Kev tswj qhov ncauj: Ib koob: 0.4 ntsiav tshuaj ib 10kg lub cev hnyav rau yaj; 0.6 ntsiav tshuaj ib 10kg lub cev hnyav rau npua.
Cov teebmeem
Dab tsi yog qhov muaj feem cuam tshuam ntawmIvermectin ntsiav tshuajnyob rau hauv ntau hom tsiaj?
Tsis muaj kev phiv tshwm sim tau raug pom thaum siv ntawm cov tshuaj pom zoo thiab kev tswj hwm..
Dab tsi yog hom tshuaj noj ntau npaum li casIvermectin ntsiav tshuaj?
5mg ib
Dab tsi yog Cov Lus Ceeb Toom ntawmIvermectin ntsiav tshuaj?
(1) Tsis siv rau hauv yaj ua kua mis rau tib neeg noj thaum lub sij hawm lactation.
(2) Ivermectin yog tshuaj lom heev rau cw, ntses, thiab lwm yam kab mob hauv dej. Tsis txhob tso cov ntim khoom lossis cov thawv ntim tshuaj uas muaj cov khoom seem pov tseg kom tsis txhob muaj dej paug.
(3) Siv ceev faj thaum thawj 45 hnub ntawm cev xeeb tub hauv cov noob qoob loo.
(4) Lub sij hawm rho tawm: yaj: 35 hnub; npua: 28d.
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